Principal Scientist

Company: MultiCare
Location: Bellingham
Posted on: July 16, 2020

Job Description:

Principal Scientist, Immune Oncology and Cellular Therapy Translational Development Company: Bristol-Myers Squibb Location: Seattle Posted on: June 24, 2020 Job Description: Join us and make a difference. We hire the best people andprovide them with a work environment that places a premium ondiversity, integrity, collaboration and personal development.Through a culture of inclusion, we create a better, more productivework environment. We believe that the diverse experiences andperspectives of all our employees help to drive innovation andtransformative business results. Principal Scientist, Immune Oncology and Cellular TherapyTranslational Development The candidate will be part of the translational research groupbased in Seattle and will have responsibility for directing thetranslational strategies of early clinical stage oncology drugdevelopment programs in immune oncology and cellular therapy fromfirst in-human studies to proof of concept. Key responsibilities ofthis role are to act as the translational lead for the clinicalprograms and develop and execute translational strategies whileworking with translational scientists and cross-functional diseaseteam and thematic research centers. Expertise in developing andqualifying biomarkers for clinical trials, and strong knowledge inimmunology and tumor biology is required. Activities includecarrying out mechanism of action studies, biomarker identification,and generation of data that supports patient stratification and thepharmacodynamic evaluation of drugs in the clinical setting. Responsibilities: In-depth knowledge of fundamentals of immunology, immune oncology,and tumor biology in solid and hematological malignancies Utilization of translational based approaches to develop newconcepts and mechanism of action hypotheses identifyingdistinguishing pharmacodynamic characteristics of compounds aloneand in combination with other therapies Knowledge of biomarker discovery and development: assaydevelopment/validation, clinical discovery of biomarkers, MoAresearch, knowledge of platforms Design and execution of primary immune cell based assays Supervise scientific and technical staff Manage internal projects in immune oncology drug development Serve on internal project teams and committees as scientificfunctional lead Work closely with corporate partners to support preclinical,translational and clinical development of cancer therapeutics. Understand the context, impact and timely communication of data Specific Duties: Implement in-vitro immunologic assays for evaluating activity andmechanism of action of immune oncology drug candidates usingprimary cell cultures and patient samples Develop in-vitro and ex-vivo assays to translate preclinical datainto clinical biomarkers for advancing drug candidates throughclinical trials Critically analyze, interpret, report experimental results; drawappropriate conclusions and design next steps Supervise Associate Scientist(s) and/or Research Associate(s) asneeded, and under the direct, but limited supervision ofmanagement Participate in team meetings to present data and provideinterpretation Establish and maintain working relationship with contractlaboratories and relevant academic collaborators Ensure that the group maintains current awareness in area ofexpertise, enhance the scientific credibility of Bristol-MyersSquibb through contributions to the scientific literature(publications/presentations) Contribute to the writing of investigator brochures, INDapplications, clinical protocols, regulatory annual reports, andother regulatory documents when appropriate Qualifications: Ph.D. degree in immunology, tumor biology or cellular biology, orpharmacology with at least 3 years of successful post-doctoralexperience, evidenced by a strong publication record, plus aminimum of 10 years of successful experience as a scientistpreferably in the biotechnology or pharmaceutical industrysetting Excellent communication and interpersonal skills demonstrated in ateam environment Expertise in developing biomarkers for clinical trials, and strongknowledge in immunology and tumor biology, knowledge ofhematopoietic malignancies desired Relevant skills include proficiency in immunological techniques(flow cytometry, intracellular staining, cytotoxicity assays,ELISA, ELISpot, etc.), cell biology (transient and stableengineering of cell lines, also using viral transduction,immunocytochemistry, microscopy), and molecular biology (molecularcloning, transient and stable gene silencing, methylation specificPCR) techniques Familiarity with data management tools and software for analyzingtranslational data sets from various assay formats. Biologicalinterpretation of high content data sets in collaboration withcomputational biology Effective team building and teamwork skills and ability to interactwith and manage research scientists, project teams, outsidecollaborators and commercial vendors Detail-oriented with the ability to identify and implement creativesolutions Ability to prioritize and manage time efficiently Keywords: Bristol-Myers Squibb, Seattle , Principal Scientist, Immune Oncology and Cellular Therapy Translational Development, Healthcare , Seattle, Washington Didn't find what you're looking for? Search again Other Healthcare Jobs Occupational Therapist - Occupational Therapy Description: The Physical Therapist is competent in the provision of patient care to either inpatient and/or outpatient populations served. 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Keywords: MultiCare, Bellingham , Principal Scientist, Other , Bellingham, Washington